What is the important significance of renal biopsy for renal disease monitoring?
Renal biopsy, called biopsy, is the only method for pathological diagnosis of kidney disease. Refers to the use of puncture needles to penetrate the living kidney tissue, take out a small amount of kidney tissue and make pathological analysis. At present, there are mainly two methods, one is open renal biopsy, the other is percutaneous renal biopsy. The latter method is widely used at home and abroad.
I. The application of renal biopsy can clearly diagnose the disease, and the coincidence rate between renal biopsy and autopsy is as high as 84 %. Especially due to the rapid development of electron microscopy and immunopathology in recent years, the diagnostic level of kidney disease has been greatly promoted.
For example, the clinical manifestation is primary type II nephrotic syndrome, but the pathology can be seen in various pathological types, such as moderate to severe mesangial proliferative Nephritis, IgA nephropathy, membranous proliferative nephritis, focal segmental glomerulosclerosis, etc. The final diagnosis should depend on pathology and immunopathology.
For example, the clinical diagnosis of chronic glomerulonephritis is more diversified. Moreover, many lesions that are easy to be missed can only be diagnosed by living kidney tissue examination, such as interstitial nephritis, IgA nephropathy, IgM nephropathy, etc.
Secondly, after a clear diagnosis is made by renal biopsy, it can provide an important basis for clinical formulation of treatment plan and revision of treatment plan. Then take the primary Nephrotic syndrome as an example, if the renal biopsy is diagnosed as a minor lesion type, the effect of hormone therapy is good. Type II nephrotic syndrome has different responses to hormone therapy depending on the pathological type. Some pathological types have achieved good results after adding cytotoxic drugs.
Tag: biopsy ,diagnosis ,nephrotic syndrome