Unexplained anemia may caused by kidney failure
The reason why renal failure can lead to anemia is mostly due to insufficient blood volume and insufficient perfusion. Let's take a look at the reasons: Unexplained anemia may caused by renal failure
First, renal failure affects hematopoiesis
In chronic renal failure, apart from the damage to the part of the kidney where erythropoietin is produced, the affinity of hemoglobin to oxygen decreases and the utilization rate of unit hemoglobin to oxygen increases. Renal ischemia is relatively minor, and the main stimulus to produce erythropoietin is reduced, resulting in a marked decrease in erythropoietin production. There are also toxins that inhibit bone marrow. Some toxic substances accumulated in blood during chronic renal failure have a direct inhibitory effect on bone marrow, resulting in hematopoietic dysfunction.
Second, renal failure leads to destruction of red blood cells
The increase of red blood cell destruction in some patients with chronic renal failure is also one of the causes of anemia, which is due to the shortening of red blood cell life due to high polyamine level in uremia. Autolysis occurs, red blood cell metabolism disorder and red blood cell fragility increase in uremia, resulting in red blood cell autolysis, and micro-vascular lesions cause damage to red blood cells due to mechanical damage.
Tag: kidney failure,anemia ,hematopoiesis
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